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e38 Atlas of Liver Biopsies
Jules L. Dienstag / Atul K. Bhan

	Figure e38-1  Acute hepatitis with lobular inflammation and hepatocellular ballooning (H&E, 10×).
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	Figure e38-2  Acute hepatitis, higher magnification, showing lobular inflammation, hepatocellular ballooning, and acidophilic bodies (arrows) (H&E, 20×).
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	Figure e38-3  Chronic hepatitis C with portal lymphoid infiltrate and lymphoid follicle containing germinal center (H&E, 10×).
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	Figure e38-4  Chronic hepatitis C with portal and lobular inflammation and steatosis (H&E, 10×).
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	Figure e38-5  Chronic hepatitis C with portal inflammation and interface hepatitis (erosion of the limiting plate of periportal hepatocytes by infiltrating mononuclear cells) (H&E, 20×).
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	Figure e38-6  Lobular inflammation with acidophilic body (apoptotic body) surrounded by lymphoid cells (H&E, 40×).
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	Figure e38-7  Chronic hepatitis B with hepatocellular cytoplasmic staining for hepatitis B surface antigen (immunoperoxidase, 20×).
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	Figure e38-8  Chronic hepatitis B with hepatocellular nuclear staining for hepatitis B core antigen (immunoperoxidase, 20×).
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	Figure e38-9  Autoimmune hepatitis with portal and lobular inflammation, interface hepatitis, and cholestasis (H&E, 10×).
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	Figure e38-10  Autoimmune hepatitis, higher magnification, showing dense plasma cell infiltrate in the portal and periportal regions (H&E, 40×).
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	Figure e38-11  Primary biliary cirrhosis with degenerating bile duct epithelium (“florid ductular lesion”) (arrow) surrounded by epithelioid granulomatous reaction and lymphoplasmacytic infiltrate (H&E, 40×).
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	Figure e38-12  Chronic hepatitis C with bridging fibrosis (arrow) (Masson trichrome, 10×).
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	Figure e38-13  Cirrhosis with architectural alteration resulting from fibrosis and nodular hepatocellular regeneration (Masson trichrome, 2×).
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	Figure e38-14  Acute cellular rejection of orthotopic liver allograft demonstrating a mixed inflammatory cell infiltrate (lymphoid cells, eosinophils, neutrophils) of the portal tract as well as endothelialitis of the portal vein (arrow) and bile duct injury (H&E, 10×).
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	Figure e38-15  Liver allograft with cytomegalovirus infection showing hepatocytes with nuclear inclusions (arrows) surrounded by a neutrophilic and lymphoid infiltrate (H&E, 10×).
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	Figure e38-16  Combined acetaminophen hepatotoxicity and alcoholic liver injury with extensive centrilobular areas of necrosis (H&E, 4×).
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	Figure e38-17  Combined acetaminophen hepatotoxicity and alcoholic liver injury at higher magnification showing necrotic centrilobular area with Mallory bodies (H&E 20×).
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	Figure e38-18  α1 antitrypsin deficiency with cytoplasmic periodic acid–Schiff (PAS)-positive, diastase-resistant globules in many hepatocytes, predominantly at the periphery of a cirrhotic nodule (PAS, 20×).
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	Figure e38-19  α1 antitrypsin deficiency with higher magnification of PAS-positive, diastase-resistant globules (PAS, 40×).
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	Figure e38-20  Cirrhosis secondary to hemochromatosis with hepatocellular carcinoma; brown hemosiderin pigment (iron) is present in the cirrhotic liver, while the hepatocellular carcinoma nodules are hemosiderin-free (H&E, 4×).
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	Figure e38-21  Cirrhosis secondary to hemochromatosis with hepatocellular carcinoma at higher magnification, demonstrating nodules of large malignant cells with highly disorganized architecture (H&E, 10×).
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	Figure e38-22  Hemochromatosis with iron stain demonstrating extensive iron deposition and characteristic pattern of pericanalicular distribution of iron (iron stain, 10×).
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	Figure e38-23  Primary sclerosing cholangitis showing cirrhosis and periductular fibrosis (Masson trichrome, 4×).
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	Figure e38-24  Primary sclerosing cholangitis showing the extrahepatic bile duct (in a liver explant obtained at the time of hepatectomy for orthotopic liver transplantation) with marked mural chronic inflammation and fibrosis as well as peribiliary glands (H&E, 2×).
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	Figure e38-25  Primary sclerosing cholangitis showing peripheral cholestasis (green) and cytoplasmic red granular staining of hepatocytes for copper (rhodanine copper stain, 20×).
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	Figure e38-26  Nonalcoholic steatohepatitis (NASH) showing steatosis, ballooned hepatocytes, and Mallory bodies with surrounding polymorphonuclear leukocytes (arrow) (H&E, 20×).
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	Figure e38-27  Nonalcoholic steatohepatitis (NASH) showing steatosis with perisinusoidal and pericellular fibrosis (H&E, 20×).
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	Figure e38-28  Acute hepatitis with submassive hepatic necrosis with marked parenchymal collapse, remnant islands of surviving hepatocytes, and a marked ductular reaction (H&E, 10×).
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	Figure e38-29  Wilson's disease showing cirrhosis, extensive collapse, and ductular reaction in a teenager with an acute presentation (H&E, 4×).
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	Figure e38-30  Wilson's disease showing extensive hepatocyte cytoplasmic red granular staining for copper in a cirrhotic nodule (rhodanine copper stain, 20×).
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