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PART 17: Neurologic Disorders
SECTION 2   Diseases of the Central Nervous System

379 Primary and Metastatic Tumors of the Nervous System
Lisa M. DeAngelis / Patrick Y. Wen

Figure 379-1  Genetic and chromosomal alterations involved in the development of primary and secondary glioblastomas. A slash indicates one or the other or both. DCC, deleted in colorectal carcinoma; EGFR, epidermal growth...
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Figure 379-2  Fluid-attenuated inversion recovery (FLAIR) MRI of a left frontal low-grade astrocytoma. This lesion did not enhance.
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Figure 379-3  Postgadolinium T1 MRI of a large cystic left frontal glioblastoma.
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Figure 379-4  Postgadolinium T1 MRI of a recurrent glioblastoma before (A) and after (B) administration of bevacizumab. Note the decreased enhancement and mass effect.
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Figure 379-5  Postgadolinium T1 MRI demonstrating a large bifrontal primary central nervous system lymphoma (PCNSL). The periventricular location and diffuse enhancement pattern are characteristic of lymphoma.
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Figure 379-6  Postgadolinium T1 MRI demonstrating multiple meningiomas along the falx and left parietal cortex.
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Figure 379-7  Postgadolinium MRI of a right vestibular schwannoma. The tumor can be seen to involve the internal auditory canal.
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Figure 379-8  Postgadolinium T1 MRI of multiple brain metastases from non-small cell lung cancer involving the right frontal (A) and right cerebellar (B) hemispheres. Note the diffuse enhancement pattern and absence of central necrosis.
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Figure 379-9  Postgadolinium MRI images of extensive leptomeningeal metastases from breast cancer. Nodules along the dorsal surface of the spinal cord (A) and cauda equina (B) are seen.
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Figure 379-10  Postgadolinium T1 MRI showing circumferential epidural tumor around the thoracic spinal cord from esophageal cancer.
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