PART 16: Endocrinology and Metabolism
SECTION 3 Disorders of Intermediary Metabolism
357 Hemochromatosis
 | Figure 357-1 Pathways of normaliron homeostasis. Dietary inorganic iron traverses the brush border membrane of duodenal enterocytes via DMT1 after reduction of ferric (Fe3+) iron to the ferrous (Fe2+) state by duodenal cytochrome B (DcytB). Iron then moves from the enterocyte to the circulation... |
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 | Figure 357-2 Sequence of events in genetic hemochromatosis and their correlation with the serum ferritin concentration. Increased iron absorption is present throughout life. Overt, symptomatic disease usually develops between ages 40 and 60, but latent disease can be detected long before this. |
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 | Figure 357-3 Algorithm for screening for HFE-associated hemochromatosis. LFT, liver function test; TS, transferrin saturation. (From EJ Eijkelkamp et al: Can J Gastroenterol 14:121, 2000; with permission.) |
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