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351 Disorders Affecting Multiple Endocrine Systems
Camilo Jimenez Vasquez / Robert F. Gagel

	Figure 351-1  Age at onset of endocrine tumor expression in multiple endocrine neoplasia type 1 (MEN 1). Data derived from retrospective analysis for each endocrine organ hyperfunction in 130 cases of MEN 1. Age at onset is the age at first symptom or, with tumors not causing symptoms, age at the time of the first abnormal finding on a...
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	Figure 351-2  Schematic depiction of the MEN1 gene and the distribution of mutations. The shaded areas show coding sequence. The closed circles show the relative distribution of mutations, mostly inactivating, in each exon. Mutation data are derived from the Human Gene Mutation Database, from which more detailed...
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	Figure 351-3  Schematic diagram of the RET protooncogene showing mutations found in MEN type 2 and sporadic medullary thyroid carcinoma (MTC). The RET protooncogene is located on the proximal arm of chromosome 10q (10q11.2). Activating mutations of two functional domains of RET tyrosine...
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