PART 15: Disorders of the Joints and Adjacent Tissues
SECTION 2 Disorders of Immune-Mediated Injury
317 Allergies, Anaphylaxis, and Systemic Mastocytosis
 | Figure 317-1 Pathways for biosynthesis and release of membrane-derived lipid mediators from mast cells. In the 5-lipoxygenase pathway leukotriene A4 (LTA4) is the intermediate from which the terminal-pathway enzymes generate the distinct final products, leukotriene C4... |
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 | Figure 317-2 Bioactive mediators of three categories generated by IgE-dependent activation of murine mast cells can elicit common but sequential target cell effects leading to acute and sustained inflammatory responses. LT, leukotriene; PAF, platelet-activating factor; PGD2, prostaglandin... |
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 | Figure 317-3 Dermographic urticarial lesion induced by stroking the forearm lightly with the edge of a tongue blade. The photograph, taken after 2 minutes, demonstrates a prominent wheal and flare reaction in the shape of an X. (Photograph provided by Allen P. Kaplan, MD, Medical... |
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 | Figure 317-4 Algorithm for the diagnosis and management of rhinitis. ENT, ear, nose, and throat; GERD, gastroesophageal reflux disease. |
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