PART 15: Disorders of the Joints and Adjacent Tissues
SECTION 1 The Immune System in Health and Disease
315 The Major Histocompatibility Complex
 | Figure 315-1 Physical map of the HLA region, showing the class I and class II loci, other immunologically important loci, and a sampling of other genes mapped to this region. Gene orientation is indicated by arrowheads. Scale is in kilobase (kb). The approximate genetic distance from DP to A... |
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 | Figure 315-2 A. The trimolecular complex of TCR (top), MHC molecule (bottom) and a bound peptide form the structural determinants of specific antigen recognition. Other panels ( |
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 | Figure 315-3 Biosynthesis of class I (A) and class II (B) molecules. A. Nascent heavy chain (HC) becomes associated with... |
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 | Figure 315-4 Specific intermolecular interactions determine peptide binding to MHC class II molecules. A short peptide sequence derived from alpha-gliadin (A.) is accommodated within the MHC class II binding groove... |
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