PART 13: Disorders of the Kidney and Urinary Tract
278 Adaption of the Kidney to Renal Injury
 | Figure 278-1 Progression of chronic renal injury. Although various types of renal injury have their own unique rates of progression, one of the best understood is that associated with type I diabetic nephropathy. Notice the early increase in glomerular filtration rate, followed by inexorable decline... |
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 | Figure 278-2 Mechanisms of renal progression. The general mechanisms of renal progression advance sequentially through six stages that include hyperfiltration, proteinuria, cytokine bath, mononuclear cell infiltration, epithelial-mesenchymal transition, and fibrosis. (Modified... |
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 | Figure 278-3 The "Trade-off Hypothesis" for Ca2+/PO42– homeostasis with progressively declining renal function. A. How adaptation to maintain Ca2+/PO42– homeostasis leads to... |
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