PART 11: Disorders of the Respiratory System
SECTION 2 Diseases of the Respiratory System
261 Interstitial Lung Diseases
 | Figure 261-1 Proposed mechanism for the pathogenesis of pulmonary fibrosis. The lung is naturally exposed to repetitive injury from a variety of exogenous and endogenous stimuli. Several local and systemic factors (e.g., fibroblasts, circulating fibrocytes, chemokines, growth factors, and clotting... |
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 | Figure 261-2 Cellular basis for the pathogenesis of interstitial lung disease. Multiple microinjuries damage and activate alveolar epithelial cells (top left), which in turn induce an antifibrinolytic environment in the alveolar spaces, enhancing wound clot formation.... |
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 | Figure 261-3 Idiopathic pulmonary fibrosis. High-resolution CT image shows bibasal, peripheral predominant reticular abnormality with traction bronchiectasis and honeycombing. The lung biopsy showed the typical features of usual interstitial pneumonia. |
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 | Figure 261-4 Nonspecific interstitial pneumonia. High-resolution CT through the lower lung shows volume loss with extensive ground-glass abnormality, reticular abnormality, and traction bronchiectasis. There is sparing on the lung immediately adjacent to the pleura. Histology showed a combination of... |
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