PART 11: Disorders of the Respiratory System
SECTION 2 Diseases of the Respiratory System
260 Chronic Obstructive Pulmonary Disease
 | Figure 260-1 Distributions of forced expiratory volume in 1 s (FEV1) values in a general population sample, stratified by pack-years of smoking. Means, medians, and ±1 standard deviation of percent predicted FEV1 are shown for each smoking group.... |
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 | Figure 260-2 Hypothetical tracking curves of FEV1for individuals throughout their life spans. The normal pattern of growth and decline with age is shown by curve A. Significantly reduced FEV1 (<65% of predicted value at age 20)... |
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 | Figure 260-3 Pathogenesis of emphysema. Upon long-term exposure to cigarette smoke, inflammatory cells are recruited to the lung; they release proteinases in excess of inhibitors, and if repair is abnormal, this leads to air space destruction and enlargement or emphysema. ECM, extracellular matrix;... |
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 | Figure 260-4 Chest CT scan of a patient with COPD who underwent a left single-lung transplant. Note the reduced parenchymal markings in the right lung (left side of figure) as compared to the left lung, representing emphysematous destruction of the lung, and mediastinal shift... |
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