PART 11: Disorders of the Respiratory System
SECTION 2 Diseases of the Respiratory System
259 Cystic Fibrosis
 | Figure 259-1 Schema describing classes of genetic mutations in CFTR gene and effects on CFTR protein/function. Note the ΔF508 mutation is a class II mutation and, like class I mutations, would be predicted to produce no mature CFTR protein in the apical membrane. CFTR, cystic fibrosis... |
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 | Figure 259-2 Comparison of ion transport properties of normal (top) and CF (bottom) airway epithelia. The vectors describe routes and magnitudes of Na+ and Cl− transport that is accompanied by osmotically driven water flow. The normal basal pattern for ion transport is... |
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