PART 10: Disorders of the Cardiovascular System
SECTION 5 Vascular Disease
241 The Pathogenesis, Prevention, and Treatment of Atherosclerosis
 | Figure 241-1 Cross-sectional view of an artery depicting steps in development of an atheroma, from left to right. The upper panel shows a detail of the boxed area below. The endothelial monolayer overlying the intima contacts blood. Hypercholesterolemia promotes accumulation... |
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 | Figure 241-2 Plaque rupture, thrombosis, and healing. A. Arterial remodeling during atherogenesis. During the initial part of the life history of an atheroma, growth is often outward, preserving the caliber of the lumen. This phenomenon of "compensatory enlargement" accounts... |
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 | Figure 241-3 Lipid lowering reduces coronary events, as reflected on this graph showing the reduction in major cardiovascular events as a function of low-density lipoprotein level in a compendium of clinical trials with statins. (Adapted from CTT Collaborators, Lancet 366:1267,... |
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 | Figure 241-4 C-reactive protein (CRP) level adds to the predictive value of the Framingham score. hsCRP, high-sensitivity measurement of CRP. (Adapted from PM Ridker et al: Circulation 109:2818, 2004.) |
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 | Figure 241-5 Evidence from the JUPITER study that both LDL-lowering and anti-inflammatory actions contribute to the benefit of statin therapy in primary prevention. See text for explanation. hsCRP, high-sensitivity measurement of C-reactive protein (CRP). (Adapted from PM Ridker... |
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