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PART 8: Infectious Diseases
SECTION 9   Spirochetal Diseases

171 Leptospirosis
Joseph M. Vinetz

Figure 171-1  Transmission electron micrograph of Leptospira interrogans serovar Icterohaemorrhagiae.
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Figure 171-2  Differentiation of pathogenic, intermediately pathogenic, and nonpathogenic (saprophytic) Leptospira species based on molecular phylogenetic analysis using the 16S rRNA gene. Scale bar indicates rate of nucleotide substitution per base pair.
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Figure 171-3  Biphasic nature of leptospirosis and relevant investigations at different stages of disease. Specimens 1 and 2 for serology are acute-phase serum samples; specimen 3 is a convalescent-phase serum sample that may facilitate detection of a delayed immune response; and specimens 4 and 5 are follow-up serum samples that...
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Figure 171-4  Severe pulmonary hemorrhage in leptospirosis. Left: Chest x-ray. Right: Gross appearance of right lower lobe of lung at autopsy. This patient, a 15-year-old in the...
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