PART 8: Infectious Diseases
SECTION 6 Diseases Caused by Gram-Negative Bacteria
142 Gas Gangrene and Other Clostridial Infections
![]() | Figure 142-1 Scanning electron micrograph of C. perfringens. |
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![]() | Figure 142-2 Radiograph of patient with spontaneous gas gangrene due to C. septicum, demonstrating gas in the affected arm and shoulder. |
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![]() | Figure 142-3 Schematic illustration of the molecular mechanisms of C. perfringens α toxin–induced platelet/neutrophil aggregates. Homotypic aggregates of platelets (not shown) and heterotypic aggregates of platelets and leukocytes are due to α toxin-induced activation of the platelet... |
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![]() | Figure 142-4 Histopathology of experimental gas gangrene due to C. perfringens, demonstrating widespread muscle necrosis, a paucity of leukocytes in infected tissues, and accumulation of leukocytes in adjacent vessels (arrows). These features are due to the effects of α and Θ toxins on muscle cells, platelets, leukocytes, and endothelial... |
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