PART 8: Infectious Diseases
SECTION 1 Basic Considerations in Infectious Diseases
120 Molecular Mechanisms of Microbial Pathogenesis
 | Figure 120-1 Bacterial surface structures. A and B. Traditional electron micrographic images of fixed cells of Pseudomonas aeruginosa.... |
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 | Figure 120-2 Entry of bacteria into epithelial cells. A. Internalization of P. aeruginosa by cultured airway epithelial cells expressing wild-type cystic fibrosis transmembrane conductance regulator, the cell receptor for bacterial ingestion. B. Entry of P. aeruginosa into murine tracheal epithelial cells after murine infection by the intranasal... |
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 | Figure 120-3 Cellular signaling pathways for production ofinflammatory cytokines in response to microbial products. Microbial cell-surface constituents interact with Toll-like receptors (TLRs), in some cases requiring additional factors such as MD-2, which facilitates the response to lipopolysaccharide (LPS) via TLR4. Although... |
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 | Figure 120-4 The NOD-like receptor (NLR) proteins NALP1b, cryopyrin/NALP3, and IPAF and the HIN-200 protein AIM2 assemble a caspase-1-activating inflammasome complex in response to specific microbial or bacterial factors. The murine NALP1b inflammasome recognizes the cytosolic presence of anthrax lethal toxin. The cryopyrin/NALP3... |
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