PART 7: Oncology and Hematology
SECTION 3 Disorders of Hemostasis
117 Arterial and Venous Thrombosis
 | Figure 117-1 Platelet activation and thrombosis. Platelets circulate in an inactive form in the vasculature. Damage to the endothelium and/or external stimuli activates platelets that adhere to the exposed subendothelial von Willebrand factor and collagen. This adhesion leads to activation of the platelet, shape change, and the... |
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 | Figure 117-2 Summary of the coagulation pathways. Specific coagulation factors ("a" indicates activated form) are responsible for the conversion of soluble plasma fibrinogen into insoluble fibrin. This process occurs via a series of linked reactions in which the enzymatically active product subsequently converts the downstream... |
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