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103 Iron Deficiency and Other Hypoproliferative Anemias
John W. Adamson

	Figure 103-1  Internal iron exchange. Normally approximately 80% of iron passing through the plasma transferrin pool is recycled from broken-down red cells. Absorption of approximately 1 mg/d is required from the diet in men, and 1.4 mg/d in women to maintain homeostasis. As long as transferrin saturation is maintained between 20–60%...
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	Figure 103-2  Laboratory studies in the evolution of iron deficiency. Measurements of marrow iron stores, serum ferritin, and total iron-binding capacity (TIBC) are sensitive to early iron-store depletion. Iron-deficient erythropoiesis is recognized from additional abnormalities in the serum iron (SI), percent transferrin saturation, the...
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	Figure 103-3  Serum ferritin levels as a function of sex and age. Iron store depletion and iron deficiency are accompanied by a decrease in serum ferritin level below 20 μg/L. (From Hillman et al, with permission.)
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	Figure 103-4  Suppression of erythropoiesis by inflammatory cytokines. Through the release of tumor necrosis factor (TNF) and interferon γ (IFN-γ), neoplasms and bacterial infections suppress erythropoietin (EPO) production and the proliferation of erythroid progenitors [erythroid burst-forming units and erythroid colony-forming...
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