PART 7: Oncology and Hematology
SECTION 1 Neoplastic Disorders
87 Cancer of the Skin
 | Figure 87-1 Atypical and malignant pigmented lesions. The most common melanoma is superficial spreading melanoma (not pictured). A. Acral lentiginous melanoma is the most common melanoma in blacks, Asians, and Hispanics and occurs as an enlarging hyperpigmented macule or plaque on the... |
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 | Figure 87-2 Major pathways involved in melanoma. The MAP kinase and AKT pathways, which promote proliferation and inhibit apoptosis, respectively, are subject to mutations in melanoma. ERK, extracellular signalregulated kinase; MEK, methylethylketone; PTEN, pentaerythritol tetranitrate. |
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 | Figure 87-3 Survival curves for patients with melanoma.A. stage I and II disease; B. stage III disease; C. stage IV by site of metastatic disease; D. stage IV according to lactate dehydrogenase level. SQ, subcutaneous. (From Balch et al, with... |
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 | Figure 87-4 Cutaneous neoplasms. A. Non-Hodgkin's lymphoma involves the skin with typical violaceous, "plum-colored" nodules. B. Squamous cell carcinoma is seen here as a hyperkeratotic crusted and somewhat eroded plaque on the... |
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